সোমবার, ২৯ এপ্রিল, ২০১৩

Sen. Boxer finds herself at odds with environmentalists

WASHINGTON ? Barbara Boxer has long been one of the Senate's environmental champions, racking up perfect scores for each of the last five years on the League of Conservation Voters' report card on key votes.

But the Californian now finds herself on the opposite side of an issue from her usual environmental allies and some of her fellow Democrats. Environmentalists are upset because she is pushing legislation that would impose deadlines for environmental reviews of water projects, a move they see as "tilting the scales" toward rushed approvals.

"It's difficult to have one of your stalwart environmental champions working to undermine one of the bedrock environmental laws," said Friends of the Earth President Erich Pica, who, like other environmentalists, was conflicted about publicly taking on a powerful longtime ally.

"I say to my friends in the environmental movement, we can't agree 100% of the time," Boxer said.

At issue is the $12-billion Water Resources Development Act. The measure, coming before the Senate next week, is a rarity on hyper-partisan Capitol Hill: It was passed unanimously out of the Boxer-chaired Environment and Public Works Committee.

Boxer disputed any effort to weaken environmental laws but acknowledged that she was seeking to end delays to crucial projects, such as those needed to protect communities from flooding.

"The environmentalists don't like to have any deadlines set so that they can stall projects forever," Boxer said. "I think it's wrong, and I have many cases in California where absolutely necessary flood control projects have been held up for so long that people are suffering from the adverse impacts of flooding."

Although she said she was open to listening to the environmentalists' concerns, in this case, "I don't think this is legitimate."

Boxer's support for the bill puts her in a tough spot, trying to balance her devotion to environmental groups with her desire to attract Republican votes for a bill she considers important to the economy and the environment.

The measure would authorize not only flood protection projects that have gained urgency after Superstorm Sandy, but also coastal restoration in the Florida Everglades and the Gulf Coast and projects aimed at promoting commerce on waterways. The bill is also expected to bring more money to Los Angeles and Long Beach for maintenance of their ports.

"It's always hard for us to go after one of our champions, particularly someone like Sen. Boxer," said Scott Slesinger, legislative director of the Natural Resources Defense Council. "We're going to have to fight our normal allies if they're going to be attacking what we think is one of the most important environmental statutes." He referred to the National Environmental Policy Act, which requires extensive reviews of projects that could affect the environment.

Slesinger said Boxer's legislation would establish deadlines for project reviews, leading to a "rush to judgment" on development that could cause significant environmental damage. Government agencies would face fines of up to $20,000 for failing to meet deadlines for project reviews, a requirement that he warned could lead to "slapdash" reviews.

"If the agencies are pressured into making decisions quickly, we will end up with projects that cause more harm than good," said Melissa Samet, senior water resources counsel for the National Wildlife Federation.

Two of Boxer's Democratic colleagues, Sens. John D. Rockfeller IV of West Virginia and Ron Wyden of Oregon, also have expressed concern about the "project acceleration" provisions.

But the senator says she is only seeking to end needless delays.

It's not the first time Boxer has surprised her allies.

A few years ago, the stalwart liberal and frequent antagonist of big business sided with Republicans to champion a tax break for multinational corporations. She also defied the majority of her own party.

At the time, she was pushing a measure eagerly sought by California's high-tech industry.

richard.simon@latimes.com

Source: http://feeds.latimes.com/~r/latimes/news/science/~3/4tAfanJ-nqI/la-na-boxer-environmentalists-20130429,0,2078952.story

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2 police shot outside Italian premier's office

ROME (AP) ? A prosecutor says Italian politicians were the intended target of a gunman who shot and wounded two policemen in a crowded square outside the premier's office in Rome.

The attack Sunday came just as Italy's new government was being sworn in elsewhere in the city. Italy has suffered political deadlock since an inconclusive February election.

Rome Prosecutor Pierfilippo Laviani told reporters he had questioned the alleged assailant, who was taken to a hospital with bruises after being wrestled to the ground.

Laviani says the "desperate" gunman had "lost work, had lost everything." He said the man "wanted to shoot politicians, but given that he couldn't reach any, he shot the Carabinieri" police at the edge of Chigi Square.

Laviani said the man "confessed everything" and didn't appear mentally unbalanced.

Source: http://news.yahoo.com/2-police-shot-outside-italian-premiers-office-115304512.html

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Army says no to more tanks, but Congress insists

WASHINGTON (AP) ? Built to dominate the enemy in combat, the Army's hulking Abrams tank is proving equally hard to beat in a budget battle.

Lawmakers from both parties have devoted nearly half a billion dollars in taxpayer money over the past two years to build improved versions of the 70-ton Abrams.

But senior Army officials have said repeatedly, "No thanks."

It's the inverse of the federal budget world these days, in which automatic spending cuts are leaving sought-after pet programs struggling or unpaid altogether. Republicans and Democrats for years have fought so bitterly that lawmaking in Washington ground to a near-halt.

Yet in the case of the Abrams tank, there's a bipartisan push to spend an extra $436 million on a weapon the experts explicitly say is not needed.

"If we had our choice, we would use that money in a different way," Gen. Ray Odierno, the Army's chief of staff, told The Associated Press this past week.

Why are the tank dollars still flowing? Politics.

Keeping the Abrams production line rolling protects businesses and good paying jobs in congressional districts where the tank's many suppliers are located.

If there's a home of the Abrams, it's politically important Ohio. The nation's only tank plant is in Lima. So it's no coincidence that the champions for more tanks are Rep. Jim Jordan and Sen. Rob Portman, two of Capitol's Hill most prominent deficit hawks, as well as Democratic Sen. Sherrod Brown. They said their support is rooted in protecting national security, not in pork-barrel politics.

"The one area where we are supposed to spend taxpayer money is in defense of the country," said Jordan, whose district in the northwest part of the state includes the tank plant.

The Abrams dilemma underscores the challenge that Defense Secretary Chuck Hagel faces as he seeks to purge programs that the military considers unnecessary or too expensive in order to ensure there's enough money for essential operations, training and equipment.

Hagel, a former Republican senator from Nebraska, faces a daunting task in persuading members of Congress to eliminate or scale back projects favored by constituents.

Federal budgets are always peppered with money for pet projects. What sets the Abrams example apart is the certainty of the Army's position.

Sean Kennedy, director of research for the nonpartisan Citizens Against Government Waste, said Congress should listen when one of the military services says no to more equipment.

"When an institution as risk averse as the Defense Department says they have enough tanks, we can probably believe them," Kennedy said.

Congressional backers of the Abrams upgrades view the vast network of companies, many of them small businesses, that manufacture the tanks' materials and parts as a critical asset that has to be preserved. The money, they say, is a modest investment that will keep important tooling and manufacturing skills from being lost if the Abrams line were to be shut down.

The Lima plant is a study in how federal dollars affect local communities, which in turn hold tight to the federal dollars. The facility is owned by the federal government but operated by the land systems division of General Dynamics, a major defense contractor that spent close to $11 million last year on lobbying, according to the nonpartisan Center for Responsive Politics.

The plant is Lima's fifth-largest employer with close to 700 employees, down from about 1,100 just a few years ago, according to Mayor David Berger. But the facility is still crucial to the local economy. "All of those jobs and their spending activity in the community and the company's spending probably have about a $100 million impact annually," Berger said.

Jordan, a House conservative leader who has pushed for deep reductions in federal spending, supported the automatic cuts known as the sequester that require $42 billion to be shaved from the Pentagon's budget by the end of September. The military also has to absorb a $487 billion reduction in defense spending over the next 10 years, as required by the Budget Control Act passed in 2011.

Still, said Jordan, it would be a big mistake to stop producing tanks.

"Look, (the plant) is in the 4th Congressional District and my job is to represent the 4th Congressional District, so I understand that," he said. "But the fact remains, if it was not in the best interests of the national defense for the United States of America, then you would not see me supporting it like we do."

The tanks that Congress is requiring the Army to buy aren't brand new. Earlier models are being outfitted with a sophisticated suite of electronics that gives the vehicles better microprocessors, color flat panel displays, a more capable communications system, and other improvements. The upgraded tanks cost about $7.5 million each, according to the Army.

Out of a fleet of nearly 2,400 tanks, roughly two-thirds are the improved versions, which the Army refers to with a moniker that befits their heft: the M1A2SEPv2, and service officials said they have plenty of them. "The Army is on record saying we do not require any additional M1A2s," Davis Welch, deputy director of the Army budget office, said this month.

The tank fleet, on average, is less than 3 years old. The Abrams is named after Gen. Creighton Abrams, one of the top tank commanders during World War II and a former Army chief of staff.

The Army's plan was to stop buying tanks until 2017, when production of a newly designed Abrams would begin. Orders for Abrams tanks from U.S. allies help fill the gap created by the loss of tanks for the Army, according to service officials, but congressional proponents of the program feared there would not be enough international business to keep the Abrams line going.

This pause in tank production for the U.S. would allow the Army to spend its money on research and development work for the new and improved model, said Ashley Givens, a spokeswoman for the Army's Ground Combat Systems office.

The first editions of the Abrams tank were fielded in the early 1980s. Over the decades, the Abrams supply chain has become embedded in communities across the country.

General Dynamics estimated in 2011 that there were more than 560 subcontractors throughout the country involved in the Abrams program and that they employed as many as 18,000 people. More than 40 of the companies are in Pennsylvania, according to Sen. Robert Casey, D-Pa., also a staunch backer of continued tank production.

A letter signed by 173 Democratic and Republican members of the House last year and sent to then-Defense Secretary Leon Panetta demonstrated the depth of bipartisan support for the Abrams program on Capitol Hill. They chided the Obama administration for neglecting the industrial base and proposing to terminate tank production in the United States for the first time since World War II.

Portman, who served as President George W. Bush's budget director before being elected to the Senate, said allowing the line to wither and close would create a financial mess.

"People can't sit around for three years on unemployment insurance and wait for the government to come back," Portman said. "That supply chain is going to be much more costly and much more inefficient to create if you mothball the plant."

Pete Keating, a General Dynamics spokesman, said the money from Congress is allowing for a stable base of production for the Army, which receives about four tanks a month. With the line open, Lima also can fill international orders, bringing more work to Lima and preserving American jobs, he said.

Current foreign customers are Saudi Arabia, which is getting about five tanks a month, and Egypt, which is getting four. Each country pays all of their own costs. That's a "success story during a period of economic pain," Keating said.

Still, far fewer tanks are coming out of the Lima plant than in years past. The drop-off has affected companies such as Verhoff Machine and Welding in Continental, Ohio, which makes seats and other parts for the Abrams. Ed Verhoff, the company's president, said his sales have dropped from $20 million to $7 million over the past two years. He's also had to lay off about 25 skilled employees and he expects to be issuing more pink slips in the future.

"When we start to lose this base of people, what are we going to do? Buy our tanks from China?" Verhoff said.

Steven Grundman, a defense expert at the Atlantic Council in Washington, said the difficulty of reviving defense industrial capabilities tends to be overstated.

"From the fairly insular world in which the defense industry operates, these capabilities seem to be unique and in many cases extraordinarily high art," said Grundman, a former deputy undersecretary of defense for industrial affairs and installations during the Clinton administration. "But in the greater scope of the economy, they tend not to be."

___

Online:

Abrams tank: http://www.army.mil/factfiles/equipment/tracked/abrams.html

__

Follow Richard Lardner on Twitter: https://twitter.com/rplardner

Source: http://news.yahoo.com/army-says-no-more-tanks-congress-insists-115422396.html

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Biden: Economic Collapse Led to McCain Loss in 2008 (ABC News)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/302015489?client_source=feed&format=rss

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রবিবার, ২৮ এপ্রিল, ২০১৩

Hitting 'reset' in protein synthesis restores myelination: Suggests new treatment for misfolded protein diseases, such as Charcot-Marie-Tooth, Alzheimer's

Apr. 26, 2013 ? A potential new treatment strategy for patients with Charcot-Marie-Tooth disease is on the horizon, thanks to research by neuroscientists now at the University at Buffalo's Hunter James Kelly Research Institute and their colleagues in Italy and England.

The institute is the research arm of the Hunter's Hope Foundation, established in 1997 by Jim Kelly, Buffalo Bills Hall of Fame quarterback, and his wife, Jill, after their infant son Hunter was diagnosed with Krabbe Leukodystrophy, an inherited fatal disorder of the nervous system. Hunter died in 2005 at the age of eight. The institute conducts research on myelin and its related diseases with the goal of developing new ways of understanding and treating conditions such as Krabbe disease and other leukodystrophies.

Charcot-Marie-Tooth or CMT disease, which affects the peripheral nerves, is among the most common of hereditary neurological disorders; it is a disease of myelin and it results from misfolded proteins in cells that produce myelin.

The new findings sere published online earlier this month in The Journal of Experimental Medicine.

They may have relevance for other diseases that result from misfolded proteins, including Alzheimer's disease, Parkinson's, multiple sclerosis, Type 1 diabetes, cancer and mad cow disease.

The paper shows that missteps in translational homeostasis, the process of regulating new protein production so that cells maintain a precise balance between lipids and proteins, may be how some genetic mutations in CMT cause neuropathy.

CMT neuropathies are common, hereditary and progressive; in severe cases, patients end up in wheelchairs. These diseases significantly affect quality of life but not longevity, taking a major toll on patients, families and society, the researchers note.

"It's possible that our finding could lead to the development of an effective treatment not just for CMT neuropathies but also for other diseases related to misfolded proteins," says Lawrence Wrabetz, MD, director of the institute and professor of neurology and biochemistry in UB's School of Medicine and Biomedical Sciences and senior author on the paper. Maurizio D'Antonio, of the Division of Genetics and Cell Biology of the San Raffaele Scientific Institute in Milan is first author; Wrabetz did most of this research while he was at San Raffaele, prior to coming to UB.

The research finding centers around the synthesis of misfolded proteins in Schwann cells, which make myelin in nerves. Myelin is the crucial fatty material that wraps the axons of neurons and allows them to signal effectively. Many CMT neuropathies are associated with mutations in a gene known as P0, which glues the wraps of myelin together. Wrabetz has previously shown in experiments with transgenic mice that those mutations cause the myelin to break down, which in turn, causes degeneration of peripheral nerves and wasting of muscles.

When cells recognize that the misfolded proteins are being synthesized, cells respond by severely reducing protein production in an effort to correct the problem, Wrabetz explains. The cells commence protein synthesis again when a protein called Gadd34 gets involved.

"After cells have reacted to, and corrected, misfolding of proteins, the job of Gadd34 is to turn protein synthesis back on," says Wrabetz. "What we have shown is that once Gadd34 is turned back on, it activates synthesis of proteins at a level that's too high -- that's what causes more problems in myelination.

"We have provided proof of principle that Gadd34 causes a problem with translational homeostasis and that's what causes some neuropathies," says Wrabetz. "We've shown that if we just reduce Gadd34, we actually get better myelination. So, leaving protein synthesis turned partially off is better than turning it back on, completely."

In both cultures and a transgenic mouse model of CMT neuropathies, the researchers improved myelin by reducing Gadd34 with salubrinal, a small molecule research drug. While salubrinal is not appropriate for human use, Wrabetz and colleagues at UB and elsewhere are working to develop derivatives that are appropriate.

"If we can demonstrate that a new version of this molecule is safe and effective, then it could be part of a new therapeutic strategy for CMT and possibly other misfolded protein diseases as well," says Wrabetz.

And while CMT is the focus of this particular research, the work is helping scientists at the Hunter James Kelly Research Institute enrich their understanding of myelin disorders in general.

"What we learn in one disease, such as CMT, may inform how we think about toxins for others, such as Krabbe's," Wrabetz says. "We'd like to build a foundation and answer basic questions about where and when toxicity in diseases begin."

The misfolded protein diseases are an interesting and challenging group of diseases to study, he continues. "CMT, for example, is caused by mutations in more than 40 different genes," he says. "When there are so many different genes involved and so many different mechanisms, you have to find a unifying mechanism: this problem of Gadd34 turning protein synthesis on at too high a level could be one unifying mechanism. The hope is that this proof of principle applies to more than just CMT and may lead to improved treatments for Alzheimer's, Parkinson's, Type 1 diabetes and the other diseases caused by misfolded proteins."

Co-authors with D'Antonio and Wrabetz are M. Laura Feltri, MD, professor of neurology and biochemistry at UB and a researcher with UB's Hunter James Kelly Research Institute at the NYS Center of Excellence in Bioinformatics and Life Sciences; Nicolo Musner, Cristina Scapin Daniela Ungaro and Ubaldo Del Carro from the San Raffaele Scientific Institute and David Ron of Cambridge and the National Institute for Health Research Cambridge Biomedical Research Centre.

Funding was provided by the National Institutes of Health, the European Community and an award to D'Antonio from the Italian Ministry of Health.

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Story Source:

The above story is reprinted from materials provided by University at Buffalo. The original article was written by Ellen Goldbaum.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. M. D'Antonio, N. Musner, C. Scapin, D. Ungaro, U. Del Carro, D. Ron, M. L. Feltri, L. Wrabetz. Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice. Journal of Experimental Medicine, 2013; 210 (4): 821 DOI: 10.1084/jem.20122005

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/_o1zELs2WuM/130426135037.htm

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শুক্রবার, ২৬ এপ্রিল, ২০১৩

Metal detectors promised for Moscow track worlds

MOSCOW (AP) -- A top official for Russia's athletics federation says metal detectors will be used at the track and field world championships in Moscow in August.

Concerns about safety increased after last week's deadly bombings at the Boston Marathon.

General secretary Mikhail Butov told The Associated Press on Thursday that metal detectors will be set up at the entrances to Luzhniki Stadium, where all events except the marathon will be held.

He says the marathon presents less of a security challenge than in Boston because the one in Moscow will be four circuits of a course from the Kremlin to the stadium area.

Source: http://news.yahoo.com/metal-detectors-promised-moscow-track-174449798.html

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Great Salt Lake Is No 'Dead Sea'

Parts of Utah's Great Salt Lake are 10 times saltier than the ocean. But the lake is host to plenty of life, including salt-loving microbes that can turn the lake's water bubblegum pink. Bonnie Baxter, director of the Great Salt Lake, discusses how the bugs might hold the secrets to better sunscreen, hydrogen fuel cells?even life on Mars.

Source: http://www.npr.org/templates/story/story.php?storyId=179224937&ft=1&f=1007

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Green Throttle Takes (A Few) Mobile Games to the ... - AllThingsD

The last time I owned a videogame console, Hypercolor shirts were in, everyone pegged their jeans, and I had a perm. In other words, it was a long time ago. (It was the Nintendo Entertainment System, by the way.)

I?m ready to get a new system now, and choosing one is proving to be a difficult decision. Microsoft?s Xbox 360, Sony?s PlayStation 3 and Nintendo?s Wii U are the most well-known and popular ones. But I don?t want to spend a lot of money, and I already have a Roku set-top box and DVD player, so I don?t necessarily need the entertainment aspects of those systems. What to get?

Enter Green Throttle. Started by one of the co-creators of the Guitar Hero videogame with two former Palm employees, Green Throttle is an app and game-controller solution that aims to turn your existing Android tablet or smartphone into a game console.

The only thing you have to buy is the Atlas game controller, which costs $40 and connects via Bluetooth. If your mobile device can be plugged into a TV for playing video, the company also sells bundles that include special cables for connecting to your HDTV. Meanwhile, the company?s free Arena application acts as the game center, where you can download titles and play games.

Green Throttle is more about enhancing the game-playing experience of mobile devices, rather than being a direct competitor to Xbox or PlayStation. And it succeeds in that goal. The controller allows for more precision and capabilities than a touchscreen. It?s also nice to be able to play games on a bigger screen. But there?s a big drawback, and that?s its lack of compatible games. There are currently fewer than a dozen games that work with Green Throttle, so it?s simply not worth buying right now ? though it has potential.

Green Throttle works with any device running on Google?s Android operating system, version 4.0 or higher. I tested it on the Google Nexus 7 and Amazon Kindle Fire HD, and setup was relatively painless.

P1040106

After turning on the Atlas controller and downloading the Arena from the Google Play Store, I went to the app?s settings menu to connect the controller. The pairing process took some time, though. Normally, when I connect a Bluetooth headset or keyboard to a smartphone or tablet for the first time, the whole process only takes a couple of minutes.

With Green Throttle, it took at least a few minutes for both tablets to find the Atlas controller. Enough time had elapsed that I thought something might be wrong, but eventually I got a prompt to connect to the controller, and I was up and running shortly after that. Fortunately, once paired, reconnections were almost instantaneous.

The controller is similar to the ones used with the Xbox 360 and PlayStation 3. It?s powered by two AA batteries (included in the package), and there are two joysticks, a directional pad, X, Y, A, B buttons, and two trigger and two shoulder buttons on the top edge of the controller. The power, start and back buttons are located in the middle. All the controls were within easy reach, and provided good feedback ? not too stiff or mushy-feeling.

P1040104

The user interface of the Green Throttle Arena game hub is pretty straightforward. There are four tabbed sections you can peruse: Home, My Games, Recommended and Settings. The latter is self-explanatory. Home features the latest Green Throttle news, recent games and featured games. My Games is where you?ll find all your downloaded titles, while Recommended surfaces editors? picks.

A couple of things were missing: One is a search feature for looking up specific titles; the other is the ability to look for games by type, such as action, puzzle, sports and so on. Green Throttle says it will add both functions in the future.

For now, this isn?t a huge issue, since there aren?t that many games. Games must be built to work with the Atlas controllers, so you can?t use them to play titles you?ve already downloaded from the Google Play store.

Currently, there are only eight available titles from the Arena game store, with six c. Green Throttle said it is adding one or two new games to the store every week, and more than 500 companies are using its software to build titles for the system, including a few well-known console game developers.

I tried all eight titles. Most are casual or retro-style arcade games. Given the limitations of a mobile device?s hardware (computing and graphics power, memory, etc.), you won?t find any really complex or graphics-intensive titles, compared to dedicated game consoles like the Xbox and PlayStation, or even the Razer Edge gaming tablet. So, if you?re looking for big-name titles like Assassin?s Creed III or BioShock Infinite, this isn?t the system for you.

P1040102

Instead, you get games like Coral Combat, a Space Invaders-type game that takes place underwater, or FishTails, a racing game where you have to collect as many coins as possible while dodging obstacles. There are also multiplayer games like Crystal Swarm, where you can team up to kill alien bugs. I played the game with a friend, using the Kindle Fire HD hooked up to my Samsung TV.

They?re all worth a try (most games are free, but APO Snow costs $1.99, and Gunslugs costs $1.49), but given their simple nature, I wasn?t drawn to play them on a regular basis, with the exception of the snowboarding game APO Snow, and Blocks Party.

Performance was smooth. Also, having a controller with physical buttons made it easy to navigate through the games and accomplish moves.

Final score: Green Throttle takes the mobile gaming experience to the next level in an affordable way, but it?s not worth it until it beefs up its game selection.

Update: Shortly after this review was originally published, Green Throttle announced six new games for the Arena app, including The Bard?s Tale and Duke Nukem 3D.

Source: http://allthingsd.com/20130425/green-throttle-takes-a-few-mobile-games-to-the-living-room/

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Fonda to add prints by dad's at Chinese Theatre

AAA??Apr. 24, 2013?10:00 AM ET
Fonda to add prints by dad's at Chinese Theatre
By SANDY COHENBy SANDY COHEN, AP Entertainment Writer?THE ASSOCIATED PRESS STATEMENT OF NEWS VALUES AND PRINCIPLES?

FILE - In this undated publicity file photo, from left, co-stars Jane Fonda, Henry Fonda, and Katharine Hepburn are pictured in character as seen from the 1981 film, "On Golden Pond." On on Saturday, April 27, 2013, Jane Fonda, the 75-year-old Oscar winner , will place her hand and footprints next to her father's in the concrete shrine to celebrity outside Hollywood's TCL Chinese Theatre. Then she'll present a special screening of the film she made with her dad, ?On Golden Pond.? The cement and cinematic tribute is part of the 2013 TCM Classic Film Festival, which is honoring Jane Fonda. (AP Photo, File)

FILE - In this undated publicity file photo, from left, co-stars Jane Fonda, Henry Fonda, and Katharine Hepburn are pictured in character as seen from the 1981 film, "On Golden Pond." On on Saturday, April 27, 2013, Jane Fonda, the 75-year-old Oscar winner , will place her hand and footprints next to her father's in the concrete shrine to celebrity outside Hollywood's TCL Chinese Theatre. Then she'll present a special screening of the film she made with her dad, ?On Golden Pond.? The cement and cinematic tribute is part of the 2013 TCM Classic Film Festival, which is honoring Jane Fonda. (AP Photo, File)

FILE - In this May 16, 1980 file photo, Henry Fonda, center, is seen on his 75th birthday with son, Peter Fonda, left, and his wife, Shirlee Fonda. On on Saturday, April 27, 2013, Jane Fonda, the 75-year-old Oscar winner , will place her hand and footprints next to her father's in the concrete shrine to celebrity outside Hollywood's TCL Chinese Theatre. Then she'll present a special screening of the film she made with her dad, ?On Golden Pond.? The cement and cinematic tribute is part of the 2013 TCM Classic Film Festival, which is honoring Jane Fonda.(AP Photo/Randy Rasmussen, file)

FILE - In this June 25, 1957 file photo, movie actor Henry Fonda, right, with his children, Jane and Peter, are shown at New York International Airport boarding a clipper airplane for Europe where they'll spend the summer seeing sights. On on Saturday, April 27, 2013, Jane Fonda, the 75-year-old Oscar winner , will place her hand and footprints next to her father's in the concrete shrine to celebrity outside Hollywood's TCL Chinese Theatre. Then she'll present a special screening of the film she made with her dad, ?On Golden Pond.? The cement and cinematic tribute is part of the 2013 TCM Classic Film Festival, which is honoring Jane Fonda.(AP Photo, File)

FILE - In this March 29, 1982 file photo, from left, Jane Fonda, her father Henry Fonda, and his wife Shirlee are shown at home, after Jane accepted the Academy Award on behalf of her father for best performance by an actor in a leading role at the 54th Academy Awards, in Los Angeles. The elder Fonda, recuperating at home, was honored for his performance in "On Golden Pond." (AP Photo/Reed Saxon)

(AP) ? Jane Fonda is planning to shed a few tears on Saturday.

That's when the 75-year-old Oscar winner will place her hand and footprints next to her father's in the concrete shrine to celebrity outside Hollywood's Chinese Theatre. Then she'll present a special screening of the film she made with her dad, 1981's "On Golden Pond." The cement and cinematic tribute is part of the 2013 TCM Classic Film Festival, which is honoring Jane Fonda.

"I am very, very excited," Fonda said in an interview this week. "I thought probably I would die and this would never happen. I'm just really thrilled that it actually is happening and not only that, but I get to put my hand and footprints right next to my father. ... I'm just so happy I'll probably cry."

The honor inspired Fonda to reflect on her career, which hasn't slowed since she returned to acting in 2005 after a 15-year hiatus.

"I've made some really good films. There's also a lot of films I wish I could do over again," she said. "But I've been lucky: I've worked with some great directors, and I feel like I'm still a work in progress as an actor. I feel like I'm still learning."

After her guest-starring stint on "The Newsroom," she's more interested than ever in television.

"I'd love to have a television series of my own," Fonda said. "I'm hoping that might happen."

A fitness pioneer, Fonda continues to focus on health and wellness with a series of videos aimed at older exercisers. She also inspired countless Oscar watchers earlier this year with her fitted, bright yellow gown, and she serves as L'Oreal's oldest spokeswoman.

"When you're younger, you don't have to put so much time into it, but also I didn't care that much. I was an activist and I didn't think so much about how I appeared," she said. "As I've gotten older, I've paid more attention to how I dress, how I look, what makeup I use, what skincare products I use... I guess one reason that I put more effort into looking good now is because I think it gives hope to other women. It takes the edge off the fear that young people have of getting older."

The wisdom and openness that come with aging are easy to wear well, and Fonda said she's happier now than ever.

"This event that's coming up where I get to put my hand and shoeprints next to my dad in front of the Chinese Theatre, it's coming at a very happy time in my life," Fonda said, "and making it even happier."

___

Follow AP Entertainment Writer Sandy Cohen on Twitter: www.twitter.com/APSandy.

___

Online:

http://filmfestival.tcm.com

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-04-24-US-People-Jane-Fonda/id-b82229cbaa144dd88592143f6cb6a69b

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বুধবার, ২৪ এপ্রিল, ২০১৩

TSX slips as gold, energy shares drag

April 22 (Reuters) - Pep Guardiola is not the only connection between Bayern Munich and Barcelona, who meet in their Champions League semi-final, first leg at the Allianz Arena on Tuesday. Both teams are dominating their leagues to an almost embarrassing extent, have won the Champions League four times apiece, share an acrimonious rivalry with Real Madrid, and owe part of their success to the flamboyant Dutchman Louis van Gaal. Both have also been in two Champions League finals in the last four years, though the Catalans won both of theirs and the Bavarians came out losers on each occasion. ...

Source: http://news.yahoo.com/tsx-may-open-higher-helped-corporate-earnings-123850702--finance.html

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MetroPCS shareholders vote to approve T-Mobile merger

It hit a few snags along the way, but T-Mobile's merger with MetroPCS now appears to be all but a done deal. Bloomberg is reporting that MetroPCS shareholders voted to approve the deal this morning, following a recommendation from two previously opposed shareholder advisory firms that the merger be approved last week -- and approval from the board before that. According to Bloomberg, the final terms of the deal give T-Mobile parent Deutsche Telekom a 74 percent stake in the new company, with MetroPCS shareholders receiving a $1.5 billion cash payment. Most notably for T-Mobile, the deal brings nine million new prepaid customers into the fold, as well as the all-important wireless spectrum that MetroPCS currently owns.

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Source: Bloomberg

Source: http://www.engadget.com/2013/04/24/metropcs-shareholders-approve-t-mobile-merger/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Use of anti-epileptic drug during pregnancy associated with increased risk of autism

Apr. 23, 2013 ? Maternal use of valproate (a drug used for the treatment of epilepsy and other neuropsychological disorders) during pregnancy was associated with a significantly increased risk of autism in offspring, according to a study in the April 24 issue of JAMA. The authors caution that these findings must be balanced against the treatment benefits for women who require valproate for epilepsy control.

"Anti-epileptic drug exposure during pregnancy has been associated with an increased risk for congenital malformations and delayed cognitive development in the offspring, but little is known about the risk of other serious neuropsychiatric disorders," according to background information in the article.

Jakob Christensen, Ph.D., of Aarhus University Hospital, Aarhus, Denmark, and colleagues evaluated the association between maternal use of valproate during pregnancy and the risk of autism spectrum disorder and childhood autism in offspring. The population-based study included all children born alive in Denmark from 1996 to 2006. National registers were used to identify children exposed to valproate during pregnancy and diagnosed with autism spectrum disorders (childhood autism [autistic disorder], Asperger syndrome, atypical autism, and other or unspecified pervasive developmental disorders). Data were analyzed and adjusted for potential confounders (factors that can influence outcomes) such as maternal age at conception, paternal age at conception, parental psychiatric history, gestational age, birth weight, sex, congenital malformations, and parity. Children were followed up from birth until the day of autism spectrum disorder diagnosis, death, emigration, or December 31, 2010, whichever came first.

The analysis included 655,615 children born from 1996 through 2006. The average age of the children at end of follow-up was 8.8 years. During the study period, 5,437 children were diagnosed with autism spectrum disorder, including 2,067 with childhood autism. The researchers identified 2,644 children exposed to antiepileptic drugs during pregnancy, including 508 exposed to valproate. The authors found that use of valproate during pregnancy was associated with an absolute risk of 4.42 percent for autism spectrum disorder and an absolute risk of 2.50 percent for childhood autism.

"In this population-based cohort study, children of women who used valproate during pregnancy had a higher risk of autism spectrum disorder and childhood autism compared with children of women who did not use valproate. Their risks were also higher than those for children of women who were previous users of valproate but who stopped before their pregnancy," the researchers write.

"Because autism spectrum disorders are serious conditions with lifelong implications for affected children and their families, even a moderate increase in risk may have major health importance. Still, the absolute risk of autism spectrum disorder was less than 5 percent, which is important to take into account when counseling women about the use of valproate in pregnancy."

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The above story is reprinted from materials provided by The JAMA Network Journals.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Jakob Christensen et al. Anti-Epileptic Drug During Pregnancy Associated With Increased Risk of Autism. JAMA, April 23, 2013

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/mind_brain/child_development/~3/w-OeQJ8eV_c/130423161855.htm

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Yves Levigne explaining, Nick Diaz and Dan Hardy fight-talkin? and more in Dana White?s video blog

UFC president Dana White released his latest video blog. This one takes a behind-the-scenes look at UFC 158 in Montreal, complete with a whole lot of bro-hugging. As you watch, turn the volume on your computer down if you're at a workplace where the F-bomb isn't OK, and keep an eye out for these moments:

-- Referee Yves Levigne talking to Antonio Carvalho about the stoppage of his bout with Darren Elkins. Levigne explained his thought process to Carvalho, which can be instructional for Carvalho and other fighters in the future. The best referees are those who are communicative, and Levigne did a good job here.

-- White's expletive-filled reaction to the excellent bout between Johny Hendricks and Carlos Condit

-- At UFC 158, Bruce Buffer made a rare mistake, calling the Condit-Hendricks bout the main event when it was the co-main. Buffer works really hard at making his announcing special, and you can see how upset he was by the mistake when he talked to White about it.

-- Nick Diaz and Dan Hardy, both men who have dropped decisions to Georges St-Pierre, talking about fighting.

Source: http://sports.yahoo.com/blogs/mma-cagewriter/yves-levigne-explaining-nick-diaz-dan-hardy-fight-145530668--mma.html

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মঙ্গলবার, ২৩ এপ্রিল, ২০১৩

Not so KGB cool: Putin blows top at his cabinet in new video

The Russian president is known for being unflappable, but a leaked video shows him shouting and cursing at his cabinet ministers over their 'extremely low' quality of work.

By Fred Weir,?Correspondent / April 17, 2013

Russia's President Vladimir Putin (c.) tours local housing during a visit to the Russian city of Elista Tuesday. A video leaked on Wednesday shows Mr. Putin shouting and cursing at his cabinet ? a deviation from his usual, cool public persona.

Alexei Druzhinin/RIA Novosti/Pool/Reuters

Enlarge

Vladimir Putin usually appears to be the cool, poker-faced tough guy the KGB once trained him to be. But a somewhat different persona is on display in a video clip leaked by a Russian news agency Wednesday.

Skip to next paragraph Fred Weir

Correspondent

Fred Weir has been the Monitor's Moscow correspondent, covering Russia and the former Soviet Union, since 1998.?

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The edited video, taken at a meeting with Russian cabinet ministers and regional leaders after journalists had been ordered to switch off their cameras, shows Mr. Putin chewing out and cursing at officials for their failure to implement his presidential election promises.

"How are we working? The quality of work is extremely low," Putin told them. "If we're going to work like that then we'll achieve [nothing]."

He then threatened to sack them all.

"If we don?t do this, we will have to admit that either I?m not working effectively, or you all are working badly and you all should leave," Putin said. "I want to draw your attention to the fact that today I am leaning towards the second option."

Putin, whose locked-down lifestyle is so secretive that his wife is rarely seen in public and no one even knows where his two grown-up daughters live, seldom lets the public see his emotional side. But recently he did permit himself a flash of televised anger over delays and cost-overruns in the preparations for next year's Sochi Winter Games ? to which he has staked his personal prestige and authorized expenditures of more than $50 billion.

The video of Putin lambasting his officials was published Wednesday on Lifenews.ru, an online tabloid that's usually Kremlin-friendly, leading some pundits to suggest that Putin may have actually wanted this outburst to be made public as well.

But Putin's press secretary, Dmitry Peskov, told journalists that the Kremlin was furious over the leak.

"What was published from the closed part of the meeting is outrageous and unacceptable from an ethical point of view," Mr. Peskov said. "We plan in the near future to make contact with the leadership of the publication, to ask for an explanation."

The Putin who is usually seen on tightly controlled Russian TV is calm, ?magisterial, adventurous, likes to schmooze with celebrities, and is deeply concerned about the fates of endangered birds and animals.

Issues such as his opulent lifestyle ? he enjoys the use of 20 lavish official residences, compared with just eight for the entire British royal family ? and his habitual tardiness for almost any meeting are almost never touched upon in the Russian media.

Nor, at least until recently, were his occasional flashes of temper.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/1EBJK2S7Sgk/Not-so-KGB-cool-Putin-blows-top-at-his-cabinet-in-new-video

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সোমবার, ২২ এপ্রিল, ২০১৩

Stem cell transplant restores memory, learning in mice

Apr. 21, 2013 ? For the first time, human embryonic stem cells have been transformed into nerve cells that helped mice regain the ability to learn and remember.

A study at the University of Wisconsin-Madison is the first to show that human stem cells can successfully implant themselves in the brain and then heal neurological deficits, says senior author Su-Chun Zhang, a professor of neuroscience and neurology.

Once inside the mouse brain, the implanted stem cells formed two common, vital types of neurons, which communicate with the chemicals GABA or acetylcholine. "These two neuron types are involved in many kinds of human behavior, emotions, learning, memory, addiction and many other psychiatric issues," says Zhang.

The human embryonic stem cells were cultured in the lab, using chemicals that are known to promote development into nerve cells -- a field that Zhang has helped pioneer for 15 years. The mice were a special strain that do not reject transplants from other species.

After the transplant, the mice scored significantly better on common tests of learning and memory in mice. For example, they were more adept in the water maze test, which challenged them to remember the location of a hidden platform in a pool.

The study began with deliberate damage to a part of the brain that is involved in learning and memory.

Three measures were critical to success, says Zhang: location, timing and purity. "Developing brain cells get their signals from the tissue that they reside in, and the location in the brain we chose directed these cells to form both GABA and cholinergic neurons."

The initial destruction was in an area called the medial septum, which connects to the hippocampus by GABA and cholinergic neurons. "This circuitry is fundamental to our ability to learn and remember," says Zhang.

The transplanted cells, however, were placed in the hippocampus -- a vital memory center -- at the other end of those memory circuits. After the transferred cells were implanted, in response to chemical directions from the brain, they started to specialize and connect to the appropriate cells in the hippocampus.

The process is akin to removing a section of telephone cable, Zhang says. If you can find the correct route, you could wire the replacement from either end.

For the study, published in the current issue of Nature Biotechnology, Zhang and first author Yan Liu, a postdoctoral associate at the Waisman Center on campus, chemically directed the human embryonic stem cells to begin differentiation into neural cells, and then injected those intermediate cells. Ushering the cells through partial specialization prevented the formation of unwanted cell types in the mice.

Ensuring that nearly all of the transplanted cells became neural cells was critical, Zhang says. "That means you are able to predict what the progeny will be, and for any future use in therapy, you reduce the chance of injecting stem cells that could form tumors. In many other transplant experiments, injecting early progenitor cells resulted in masses of cells -- tumors. This didn't happen in our case because the transplanted cells are pure and committed to a particular fate so that they do not generate anything else. We need to be sure we do not inject the seeds of cancer."

Brain repair through cell replacement is a Holy Grail of stem cell transplant, and the two cell types are both critical to brain function, Zhang says. "Cholinergic neurons are involved in Alzheimer's and Down syndrome, but GABA neurons are involved in many additional disorders, including schizophrenia, epilepsy, depression and addiction."

Though tantalizing, stem-cell therapy is unlikely to be the immediate benefit. Zhang notes that "for many psychiatric disorders, you don't know which part of the brain has gone wrong." The new study, he says, is more likely to see immediate application in creating models for drug screening and discovery.

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The above story is reprinted from materials provided by University of Wisconsin-Madison. The original article was written by David Tenenbaum.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Yan Liu, Jason P Weick, Huisheng Liu, Robert Krencik, Xiaoqing Zhang, Lixiang Ma, Guo-min Zhou, Melvin Ayala, Su-Chun Zhang. Medial ganglionic eminence?like cells derived from human embryonic stem cells correct learning and memory deficits. Nature Biotechnology, 2013; DOI: 10.1038/nbt.2565

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/Dn4FJ19YaLw/130421151613.htm

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Syrian opposition warns Hezbollah to stay out

BEIRUT (AP) ? The Syrian opposition called on Hezbollah to withdraw its fighters from the country immediately, as activists said regime troops supported by pro-government gunmen linked to the Lebanese Shiite militant group battled rebels Sunday for control of a string of villages near the Lebanon-Syria border.

The Syrian National Coalition ? the main Western-backed opposition group ? warned that Hezbollah involvement in Syria's civil war could lead to greater risks in the area, and urged the Lebanese government to "adopt the necessary measures to stop the aggression of Hezbollah" and to control the border to "prevent further risks and to protect civilians in the area."

The statement, posted on the Coalition's Facebook page, coincides with a surge in fighting around the contested town of Qusair in Syria's Homs province near the frontier with Lebanon. Over the past two weeks, the Syrian military, supported by pro-regime militia backed by Hezbollah, has pushed to regain control of the border area ? a strategic region because it links Damascus with the Mediterranean coastal enclave that is the heartland of President Bashar Assad's Alawite sect, an offshoot of Shiite Islam.

It also points to the sectarian nature of the Syrian conflict, which pits a government dominated by the president's Alawite minority against a primarily Sunni Muslim rebellion, as well as fears that the civil war could drag in neighboring states.

The pro-regime gunmen are members of the Popular Committees, which were set up last year in Syria with Hezbollah's backing to protect Syrian villages inhabited by Lebanese Shiites, although rebels accuse the fighters of attacking opposition villages in the area and fighting alongside government forces.

While Hezbollah confirms backing the Popular Committees, it denies taking part in Syria's civil war.

The fighting along the border region has flared in recent weeks, and on Saturday?government forces captured the villages of Radwaniyeh and Tel al-Nabi Mando. On Sunday, regime forces shelled the villages of Abu Houri, Saqarigh, Nahriyeh and Ein al-Tanour in the Qusair region, according to the Britain-based Syrian Observatory for Human Rights activist group. It said at least four rebels were killed in the fighting.

Syrian state television said the army was trying to "uproot all the terrorists from the area." The government, which denies it is facing a popular uprising, describes the revolt as a foreign-backed plot and calls those trying to topple it "terrorists."

Lebanon's state-run news agency reported two shells fired from Syria landed Sunday in the town of Hermel near the frontier with Syria, causing material damage but no casualties. A day earlier, two mortar rounds landed in the town for the first time, marking an escalation in violence along the already tense border.

Syria's 2-year-old conflict has repeatedly spilled over into neighboring states, while the violence at home has forced more than 1 million Syrians to escape their homeland to seek safety abroad. Most of the refugees have fled to Lebanon, Jordan, Iraq and Turkey, where they have put an immense burden on already cash-strapped governments to cope with huge influx.

In Jordan, police arrested eight Syrians on suspicion of inciting riots at the sprawling Zaatari refugee camp, according to a Jordanian security official who requested anonymity in line with regulations.

About 100 Syrian refugees threw stones at Jordanian police on Friday for preventing some of them from sneaking out of their desert camp. Ten police officers were injured, including two who remain in critical condition.

The security official said a military prosecutor was set to question the eight suspects later Sunday. If convicted, they face up to three years in jail.

The Zaatari camp houses 150,000 Syrian refugees, while another 350,000 Syrians have found shelter in Jordanian communities. Conditions in the overcrowded camp have worsened since it opened last July, and there have been several riots.

In Damascus, a senior Iranian lawmaker on Sunday expressed support for Assad, and said that what he called the U.S.-led battle to oust the Syrian leader had failed.

Alaeddin Boroujerdi, the head of Iran's parliamentary?committee on national interest and?foreign policy, said Tehran is "happy that?the U.S., with its abilities and regional allies, has failed despite its efforts" to topple Assad.

"Today, they are the losers in the game, no doubt," Boroujerdi told Iranian state TV ahead of talks with Syrian Foreign Minister Walid al-Moallem.

Iran is Syria's chief regional ally.

Al-Moallem repeated the government line that Syria is the victim of a foreign conspiracy hatched by the United States in cooperation with Syria's neighbors. Damascus has previously rebuked Saudi Arabia and Qatar for financing arms purchases to the rebels, and Turkey and Jordan for allowing arms shipments.

The U.S. has long called for Assad to leave power, but for months did not play an active role in backing the rebellion. Recently, however, Washington has grown more assertive, helping cobble together the Syrian National Coalition late last year in the hopes that it could unite the deeply divided opposition and provide a conduit for aid to the rebels.

At an international conference on Saturday in Istanbul that brought together the opposition leadership and its chief international supporters, U.S. Secretary of State John Kerry announced that the Obama administration would double its non-lethal assistance to the Syrian opposition with an additional $123 million in supplies. That could include for the first time armored vehicles, body armor, night vision goggles and other defensive military supplies, officials said.

The additional aid brings total non-lethal U.S. assistance to the opposition to $250 million since the fighting began more than two years ago. Washington has refused so far to provide weapons to Syria's rebels out of fears they could fall in the hands of extremists.

The U.S. pledge was the only tangible, public offer of new international support at the meeting of the foreign ministers of the 11 main countries supporting the opposition and fell well short of what the opposition has been appealing for: weapons and direct military intervention to stop the violence that has killed more than 70,000 people.

The Syrian National Coalition is seeking drone strikes on sites from which the regime has fired missiles, the imposition of no-fly zones and protected humanitarian corridors to ensure the safety of civilians.

___

Associated Press writers Jamal Halaby in Amman, Jordan, and Maamoun Youssef in Cairo contributed to this report.

Source: http://news.yahoo.com/syrian-opposition-warns-hezbollah-stay-162204111.html

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রবিবার, ২১ এপ্রিল, ২০১৩

Fishing Season Opens Saturday In Fairfield | The Fairfield Daily Voice

FAIRFIELD COUNTY, Conn. -- Anglers are grabbing their poles and bait and heading outdoors as trout fishing season opens Saturday throughout Fairfield County and Connecticut.?

The state?s rivers, streams, lakes and ponds are stocked and ready,?the state Department of Energy and Environmental Protection announced this week. About 381,000 trout were released this spring into 102 lakes and ponds and 200 rivers and streams throughout Connecticut, it said.

The department's spring trout stocking effort began in early March and will continue through the end of May. When the spring stockings are completed, more than 630,000 trout will have been released.

?Opening Day is an exciting time for Connecticut?s many trout anglers, and they can look forward to exceptional fishing this season,? said Susan Whalen, deputy commissioner of DEEP. ?The fish are in excellent condition, nearly all of our trout waters are stocked and anglers can enjoy a wide range of fishing options. Additionally, Opening Day is a special time for many families, the traditional first time to get outdoors together after winter.?

Many trout fishing areas have special regulations Fishermen should consult the 2013 CT Angler?s Guide for detailed information on specific locations and angling regulations. Electronic versions of the 2013 Guide can be found on the DEEP website. Print versions of the 2013 Angler?s Guide are available at more than 350 locations statewide, including town halls, bait and tackle shops and other vendors selling outdoor equipment, DEEP facilities, and commercial marinas and campgrounds.

Fishing and fisheries related information can be found on this DEEP website?or Facebook page.

Maps of all of the state?s trout streams and rivers showing the many stocking and access points can be found at www.ct.gov/deep/troutstockingmaps.

Anglers can purchase their 2013 fishing licenses online or at one of the many participating town halls, tackle retailers and DEEP offices.?

The state began stocking fish throughout the state last month. Read more about that on The Daily Voice website.?

Source: http://fairfield.dailyvoice.com/sports/fishing-season-opens-saturday-fairfield-county

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Study Finds Scientific Basis for 'Chemo Brain' in Breast Cancer ...

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Study Finds Scientific Basis for ?Chemo Brain? in Breast Cancer Patients




By Janice Wood Associate News Editor
Reviewed by John M. Grohol, Psy.D. on April 19, 2013

chemo brainWhile breast cancer patients often report difficulties with memory, concentration and other cognitive functions following treatment, there?s been a debate in the medical community as to whether this mental fogginess is psychosomatic or a symptom of changes in brain function.

Now, a new study has shown a correlation between poorer performance on neuropsychological tests and memory complaints in post-treatment, early-stage breast cancer patients, particularly those who have undergone chemotherapy and radiation.

?The study is one of the first to show that such patient-reported cognitive difficulties ? often referred to as ?chemo brain? in those who have had chemotherapy ? can be associated with neuropsychological test performance,? said Dr. Patricia Ganz, director of cancer prevention and control research at the University of California-Los Angeles?s Jonsson Comprehensive Cancer Center.

Ganz and her colleagues looked at 189 breast cancer patients who enrolled in the study about a month after completing their initial breast cancer treatments and before beginning endocrine hormone-replacement therapy. Two-thirds had breast-conserving surgery, more than half had received chemotherapy, and three-quarters had undergone radiation therapy. Average age of the women was 52.

Because cognitive complaints following cancer treatment have often been associated with anxiety and depressive symptoms, the researchers excluded women with serious depressive symptoms. They also took into account the cancer treatments used and whether menopause and hormonal changes could be influencing the cognitive complaints. A group of healthy women of about the same age was used as a control group.

The researchers gave a self-reporting questionnaire to the women and found that those with breast cancer reported more severe complaints than normal ? 23.3 percent had higher complaints about their memory, and 19 percent reported higher complaints about higher-level cognition, such as problem-solving and reasoning.

The researchers noted that the breast cancer patients who reported more severe memory and higher-level cognition problems were more likely to have undergone both chemotherapy and radiation.

The UCLA researchers found that even when patients reported subtle changes in their memory and thinking, neuropsychological testing showed detectable differences.

For instance, they discovered that poorer performance on the neuropsychological test was associated with higher levels of cognitive complaints and with combined radiation and chemotherapy treatment, as well as with symptoms related to depression.

?In the past, many researchers said that we can?t rely on patients? self-reported complaints or that they are just depressed, because previous studies could not find this association between neuropsychological testing and cognitive complaints,? Ganz said. ?In this study, we were able to look at specific components of the cognitive complaints and found they were associated with relevant neuropsychological function test abnormalities.?

The findings are part of an ongoing study that seeks to examine the extent to which hormone therapy contributes to memory and thinking problems in breast cancer survivors, she said. This latest study provided a pre-hormone therapy assessment, which was able to separate the effects of initial treatments on these cognitive problems, she said. Earlier post-treatment studies of breast cancer patients were difficult to interpret, as they included women already taking hormone therapy, she noted.

?As we provide additional reports on the follow-up testing in these women, we will track their recovery from treatment, as well as determine whether hormone therapy contributes to worsening complaints over time,? Ganz said.

The study was published in the Journal of the National Cancer Institute.

Source: University of California-Los Angeles

Breast cancer patient photo available from Shutterstock

APA Reference
Wood, J. (2013). Study Finds Scientific Basis for ?Chemo Brain? in Breast Cancer Patients. Psych Central. Retrieved on April 20, 2013, from http://psychcentral.com/news/2013/04/20/study-finds-scientific-basis-for-chemo-brain-in-breast-cancer-patients/53922.html

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Source: http://psychcentral.com/news/2013/04/20/study-finds-scientific-basis-for-chemo-brain-in-breast-cancer-patients/53922.html

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শনিবার, ২০ এপ্রিল, ২০১৩

New potential target for cancer therapy identified

Apr. 19, 2013 ? Researchers at UT Southwestern Medical Center have found that alternative splicing -- a process that allows a single gene to code for multiple proteins -- appears to be a new potential target for anti-telomerase cancer therapy.

The enzyme telomerase is overexpressed in almost all cancer cells, and previous research efforts have failed to identify good telomerase inhibitors. The study by Dr. Woodring Wright and UT Southwestern colleagues in the April 4 issue of Cell Reports identifies a new approach for inhibiting telomerase, which is an enzyme that drives uncontrolled division and replication of cancer cells.

Alternative splicing allows genetic information to be assembled in different ways and is almost always controlled by DNA sequences that are immediately adjacent to the parts of a gene that code for protein. "In the case of the telomerase gene, we found that these controlling regions are located very far from the protein coding regions and that they contain unusual DNA sequences," said Dr. Wright, professor of cell biology and internal medicine. "Their unusual DNA structure suggests that humans regulate telomerase in a very different fashion that we may be able to exploit to develop inhibitors of the enzyme."

Most of the splice variants that telomerase makes are inactive, but Dr. Wright's team demonstrated that it was possible to shift the splicing to make even less active telomerase, potentially providing a new approach for cancer therapy.

Telomeres are specialized structures at the ends of each chromosome. As DNA replicates, telomeres shorten each time a cell divides. Telomerase in human cancer cells is 10 to 20 times more active than in normal body cells. The increase provides a selective growth advantage to many types of tumors. If telomerase activity was to be turned off, then telomeres in cancer cells would shorten like they do in normal body cells.

"The oft-used analogy is that telomeres are like the plastic ends of shoelaces that protect them from fraying," Dr. Wright said. "Once the plastic becomes damaged and falls off, the shoelace can no longer be threaded effectively. The only solution at that point is to throw the shoelace away."

In most tissues, telomerase turns off during development, after which telomeres shorten and limit the number of times a cell can divide, eventually losing their capping function similar to the shoelace tip falling off. This timing also functions as a tumor-protection mechanism, since the limited cellular lifespan prevents pre-malignant cells from accumulating the mutations they need to become cancerous.

Preclinical studies have shown that inhibiting telomerase causes tumor cells to lose immortality, re-initiate telomere shortening, and eventually die. In the event that a tumor has already thoroughly developed, it may be surgically removed, and following conventional chemotherapy, telomerase inhibition could prevent rare surviving cells from having enough divisions to cause a relapse.

Dr. Wright said the alternative splicing method also could be useful for regenerative medicine, because telomeres in our stem cells shorten with age and that eventually compromises their function. "Under the right circumstances, increasing or decreasing telomerase activity could profoundly affect our treatments for both cancer and aging," he said.

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Story Source:

The above story is reprinted from materials provided by UT Southwestern Medical Center, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Mandy?S. Wong, Ling Chen, Christopher Foster, Radhika Kainthla, Jerry?W. Shay, Woodring?E. Wright. Regulation of Telomerase Alternative Splicing: A Target for Chemotherapy. Cell Reports, 2013; DOI: 10.1016/j.celrep.2013.03.011

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/yGGk58a8mm8/130419160713.htm

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Gameloft releases a new Iron Man 3 trailer

This 'endless runner in the sky' is almost ready for an official release

You may have heard that the official Iron Man 3 game is hitting Android (and iOS) on April 25, but Gameloft is making sure everyone stays excited about it. In the latest gameplay trailer, you get a better look at everything Iron Man 3 will have to offer. You get a better look at not only the exciting gameplay of flying, shooting and dodging obstacles, but also the entire "Stark Industries" side of things with the new suits, armor and upgrades available.

Take a look at the video above for one more glimpse of the new gameplay, and be sure to check out our initial hands-on with the game at GDC just a few weeks ago.

    


Source: http://feedproxy.google.com/~r/androidcentral/~3/glIeb4VJNk8/story01.htm

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শুক্রবার, ১৯ এপ্রিল, ২০১৩

Iran upgrades its nuclear technology, diplomats say

VIENNA (AP) ? Technicians upgrading Iran's main uranium enrichment facility have tripled their installations of high-tech machines that could be used in a nuclear weapons program to more than 600 in the last three months, diplomats said Wednesday.

They say the machines are not yet producing enriched uranium and some may be only partially installed. Still the move is the latest sign that 10 years of diplomatic efforts have failed to persuade Tehran to curb its uranium enrichment. Instead, Iran continues to increase its capacities.

The installations also suggest that Iran possesses both the technology to mass-produce centrifuges that can enrich much faster than its present machines and the ability to evade international sanctions meant to keep it from getting materials it needs to do so.

The Islamic Republic insists it has no interest in nuclear weapons and says it's enriching uranium only for nuclear power and other non-military applications. Iran also asserts it has a right to do so under international law.

But the United States, Israel and their allies fear Iran may use the technology to create weapons-level uranium that can be used in an atomic bomb. They base their concerns on Tehran's nuclear secrecy and suspicions they share with the International Atomic Energy Agency?that Iran may have worked secretly on nuclear arms.

Experts for years have suggested that the U.N. embargoes against Tehran for defying Security Council demands that it stop enrichment has left Tehran short of high-quality steel, carbon fiber and other materials needed to establish a production line of advanced centrifuges.

But the installations that began early this year and recent Iranian comments indicate the expansion has just begun.

An IAEA report in February said agency inspectors counted 180 of the advanced IR-2m centrifuges at Natanz, Tehran's main enrichment site, less than a month after Iran's Jan. 23 announcement that it would start mounting them. The report said it was unclear whether the machines were partly or completely installed.

Two diplomats who spoke to The Associated Press said while IAEA experts visiting the Iranian sites were now able to count more of the centrifuges, they remained uncertain about their operating ability because they were not permitted to get a close enough look.

One of the diplomats who spoke comes from a country critical of Iran's nuclear program while the other is considered neutral, and both spend much of their time probing Iran's nuclear activities. They demanded anonymity because they were not authorized to discuss confidential information about IAEA inspections.

A phone call for reaction to Ali Asghar Soltanieh, Iran's chief IAEA representative, was not returned. The IAEA said it would not comment on the diplomats' report.

The February IAEA report also said the number of other advanced centrifuge models being tested at an R&D site at Natanz separate from its enrichment plant had substantially increased to more than 300 as of February.

Iranian nuclear chief Fereidoun Abbasi was quoted Sunday by the semiofficial Fars news agency as saying that more than 3,000 high-tech centrifuges have already been produced and will soon phase out the more than 12,000 older-generation enriching machines at Natanz.

If accurate, those numbers show that Iran has managed to outperform expectations published just two years ago. Back then David Albright of the Washington-based Institute for Science and International Security cited unnamed U.S. government sources estimating that raw-material shortages would likely limit production of the advanced machines to no more than 1,000.

Albright on Wednesday said Iran's apparent ability to mass-produce the machines reflects its success in evading sanctions.

"At this point you have to concede that Iran probably has the material to make up to 3,000 IR2-ms," he said.

Albright, who occasionally briefs U.S. government officials on Iran's nuclear program, said much of the material appears to be coming through China from European and Japanese manufacturers. He cited non-U.S. Western government sources for his information but said he could not divulge precise nationalities.

At the present installation rate of about 200 a month, it would take 15 months from the startup date to install the 3,000 high-tech centrifuges mentioned by Abbasi. That would mean all would be in place by May 2014.

The new IR-2ms are believed to be able to enrich two to five times faster than the old machines. For nations fearing that Iran may want to make nuclear arms, that would mean a quicker way of getting there.

But some nations and individuals say concerns that Iran will use the technology for weapons are misplaced without proof that it aims to do so. As such, they support Iran's claim that Security Council sanctions because of its refusal to stop enriching are illegal.

Under the nuclear Nonproliferation Treaty "there is no legal mechanism to limit Iran's enrichment capacity," said nuclear scientist Yousaf Butt, of the Monterey Institute of International Studies.

He also argued that it could take some time to have the new machines work properly based on reports that those now operation "are inefficient and prone to breakdown."

"The newer ones will take some time to test and de-bug ... (and) may not even work at their design capacity for years," he said.

Even then, the up-grade reflects Iranian resistance to attempts by six nations ? the United States, Russia, China, Britain, France and Germany ? which are trying to persuade Iran to curb its nuclear program. The latest Iran-six power talks ended April 6 without progress in Almaty, Kazakhstan. That extended years of inconclusive negotiations and increased fears that the diplomatic window on reaching a deal on Iran's nuclear program may soon close.

Israel accuses Tehran of striving to make nuclear weapons and has threatened to bomb its atomic facilities to stop it from reaching that alleged goal if talks fail. The United States also has not ruled out such action as a last resort.

Source: http://news.yahoo.com/apnewsbreak-diplomats-iran-ups-nuke-technology-105817545.html

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